antidromic activation - significado y definición. Qué es antidromic activation
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Qué (quién) es antidromic activation - definición

Antidromic conduction; Antidromal; Antidromic response

Antidromic         
An antidromic impulse in an axon refers to conduction opposite of the normal (orthodromic) direction. That is, it refers to conduction along the axon away from the axon terminal(s) and towards the soma.
CRISPR activation         
  • The dCas9-VPR activator increases transcription at the gene that it targets.
  • The use of the Suntag system allows multiple antibodies fused to VP64 to bind to dCas9-Suntag. That in turn recruits RNA polymerase and increases gene expression.
  • The dCas-SAM system uses msgRNA that has attached aptamers for different transcriptional factors (MS2,p65 and HSF1) to bind.
  • Complementary base pairing between the sgRNA and genomic DNA allows targeting of Cas9 or dCas9
PROGRAMMABLE TRANSCRIPTIONAL ACTIVATOR
User:Mjlink/sandbox; DCas9 Activation Systems; DCas9; SunTag; DCas9 activation system
CRISPR activation (CRISPRa) is a type of CRISPR tool that uses modified versions of CRISPR effectors without endonuclease activity, with added transcriptional activators on dCas9 or the guide RNAs (gRNAs).
antidromic         
[?ant?'dr??m?k]
¦ adjective Physiology (of an impulse) travelling in the opposite direction to that normal in a nerve fibre. The opposite of orthodromic.
Origin
early 20th cent.: from anti- + Gk dromos 'running' + -ic.

Wikipedia

Antidromic

An antidromic impulse in an axon refers to conduction opposite of the normal (orthodromic) direction. That is, it refers to conduction along the axon away from the axon terminal(s) and towards the soma. For most neurons, their dendrites, soma, or axons are depolarized forming an action potential that moves from the starting point of the depolarization (near the cell body) along the axons of the neuron (orthodromic). Antidromic activation is often induced experimentally by direct electrical stimulation of a presumed target structure. Antidromic activation is often used in a laboratory setting to confirm that a neuron being recorded from projects to the structure of interest.